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May 8, 2026Open Access

Histomorphological and Molecular Changes in Ovarian Tissue in an Experimental Model of Polycystic Ovary Syndrome-Like Disorders.

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Authors

ZIZiyodaxon Jaloliddinovna IbragimovaFerghana Polytechnical Institute

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Overview

Randomized trial investigates ovarian tissue changes in rat model of PCOS, suggesting multi-target therapeutic strategies.

Key Points

  • The aim is to explore histomorphological and molecular changes in ovarian tissue associated with PCOS-like disorders.
  • Used a letrozole-induced model in 40 Wistar rats, randomized into control and PCOS groups.
  • Administered letrozole (1 mg/kg) for 21 days to induce PCOS.
  • Evaluated hormonal changes, estrous cycle disruption, and ovarian morphology post-treatment.
  • Folliculogenesis disruption with reduced preantral/antral follicles and increased atresia observed.
  • Elevated inflammation markers (TNF-α, IL-6) and impaired signaling (CYP17A1 upregulated, CYP19A1 downregulated).
  • Indicated oxidative stress with higher ROS and MDA levels, alongside decreased antioxidant defenses.

Cite This Study

Ziyodaxon Jaloliddinovna Ibragimova (2026) studied this question.

synapsesocial.com/papers/69fd7fb8bfa21ec5bbf083d2https://doi.org/10.5281/zenodo.20056566
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polycystic Ovarian Syndrome (PCOS): A Brief Overview on Pathogenesis, Main Signaling Pathways, and Recent Studies Performed on Letrozoleinduced PCOS in Rodents2026
  2. 2ANIMAL MODELS AND MECHANISM OF ACTION OF POLYCYSTIC OVARIAN SYNDROME: A REVIEW2024 · 1 citations
  3. 3Reproductive and Cardiometabolic Characterization of a Letrozole- and High-Fat Diet-Induced PMOS-like Rat Model: An Experimental Study2026
  4. 4Ameliorative potential of rosmarinic acid in a rat model of polycystic ovary syndrome: Targeting MCP‐1 and VEGF: A histological, immunohistochemical, and biochemical study2024 · 3 citations
  5. 5The Histological and Hormonal Effects of Irisin on Polycystic Ovary Syndrome Induced by Letrozole in Adult Female Rats2024