What question did this study set out to answer?

This study aims to describe outcomes and salvage management strategies for large B‐cell lymphoma patients relapsing after second-line CAR T‐cell therapy.

May 8, 2026HemaSphereOpen Access

Outcomes and salvage strategies for large B‐cell lymphoma progressing after second‐line CAR T‐cell therapy: A DESCAR‐T study from the LYSA group

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This study aims to describe outcomes and salvage management strategies for large B‐cell lymphoma patients relapsing after second-line CAR T‐cell therapy.
Multicenter retrospective study utilizing the French DESCAR‐T registry
Analyzed 297 patients with large B‐cell lymphoma relapsing after 2L CAR T‐cell therapy
Evaluated treatment types, response rates, and prognostic factors.
Overall response rate after relapse was 39.1%, with a complete response rate of 27.6%
Median overall survival after relapse was 6.5 months
Multivariate analysis identified early relapse, ECOG score ≥ 2, and elevated C-reactive protein as poor prognostic indicators.

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Implication

Retrospective study explores post-relapse outcomes of CAR T‐cell therapy in large B‐cell lymphoma, indicating urgent need for new treatments.

Cite This Study

Sesques et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fb8bfa21ec5bbf083e0 https://doi.org/10.1002/hem3.70356

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Implication

Retrospective study explores post-relapse outcomes of CAR T‐cell therapy in large B‐cell lymphoma, indicating urgent need for new treatments.

Outcomes and salvage strategies for large B‐cell lymphoma progressing after second‐line CAR T‐cell therapy: A DESCAR‐T study from the LYSA group

Key Points

Discussion

Implication

Cite This Study

Outcomes and salvage strategies for large B‐cell lymphoma progressing after second‐line CAR T‐cell therapy: A DESCAR‐T study from the LYSA group

Key Points

Discussion

Implication

Cite This Study

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