Randomized trial shows how to create treatment hierarchies using covariate profiles for major depressive disorder, suggesting improved decision-making.
Network meta-analysis (NMA) is an increasingly popular evidence synthesis tool that can provide a ranking of competing treatments, also known as a treatment hierarchy. Treatment-covariate interactions (TCIs) can be included in NMA models to allow relative treatment effects to vary with covariate values. We show that in an NMA model that includes TCIs, treatment hierarchies should be created with a particular covariate profile in mind. We outline the typical approach for creating a treatment hierarchy in standard Bayesian NMA and show how a treatment hierarchy for a particular covariate profile can be created from an NMA model that estimates TCIs. We demonstrate our methods using a real network of studies for the treatment of major depressive disorder.
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Wigle et al. (2026) studied this question.
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