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This research aims to develop and evaluate antibiotic-loaded latex beads for targeting bone infections like osteomyelitis.

Antibiotic-Loaded Ready-to-Use Latex Beads for Localized Treatment of Bone Infections

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Randomized trial evaluates antibiotic-loaded beads for bone infection treatment, suggesting effective local delivery.

This research aims to develop and evaluate antibiotic-loaded latex beads for targeting bone infections like osteomyelitis.
Produced antibiotic-loaded beads using a solvent-free droplet approach with controlled aggregation of latex nanoparticles.
Incorporated ampicillin to assess antimicrobial effectiveness and tested biocompatibility with Saos-2 osteoblast cells.
Conducted in vivo evaluations to confirm efficacy in infection control and tissue integration.
The beads demonstrated prolonged antibacterial activity against Staphylococcus aureus biofilms (p<0.05).
In co-culture systems, the beads maintained Saos-2 cell viability while selectively inhibiting bacterial growth.
In vivo results indicated successful integration and infection control.

Sekar et al. (2026) studied this question.

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