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May 8, 2026Journal of the American College of CardiologyOpen Access

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

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Why the study?

HFpEF involves multiple pathophysiological mechanisms causing heterogeneous phenotypes that have confounded previous trials, requiring better biological understanding to guide targeted therapies.

Design

Review

Authors

GLGavin A. LewisUniversity of LiverpoolESErik B. SchelbertCardiac ImagingSWSimon G. WilliamsHeart Failure & Transplant

Discussion

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Implication

Should not yet alter HFpEF management; leaves open which biological phenotypes are causal targets for therapy.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Lewis et al. (2017) studied this question.

synapsesocial.com/papers/69fdaa84a57f1b069b22ee4chttps://doi.org/10.1016/j.jacc.2017.09.006

Topics

HFrEF treatmentHeart failure
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Also Consider

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  5. 5Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction2012 · 100 citations