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Reveals tRNA methylation drives liver cancer stem cell self-renewal via cholesterol synthesis, highlighting a therapeutic target.
A methylation in a subset of tRNA to increase PPARδ translation, which in turn triggers cholesterol synthesis to activate Hedgehog signaling, eventually driving self-renewal of liver CSCs and tumourigenesis. Finally, we identify a potent inhibitor against TRMT6/TRMT61A complex that exerts effective therapeutic effect on liver cancer.
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Wang et al. (2021) studied this question.
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