January 3, 2013Circulation ResearchOpen Access

Crucial Role for Ca ²⁺ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

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Population

CaMKIIδ/γ double-knockout mice, transgenic CaMKIIδC-overexpressing mice, wild-type mice, and human end-stage…

Comparison

CaMKII genetic manipulation and in vitro CaMKII… vs Wild-type mice and nonfailing human donor hearts

Design

Preclinical

Authors

NHNazha HamdaniHeart Failure & Transplant JKJudith KrysiakRuhr University Bochum MKMichael M. KreußerHeidelberg University

Discussion

Member takes

Implication

Hypothesis-generating for diastolic stiffness modulation in heart failure; human validation required before clinical consideration.

Structured PICO

Population

CaMKIIδ/γ double-knockout (DKO) mice, transgenic CaMKIIδC-overexpressing mice, wild-type (WT) mice, and human end-stage failing and nonfailing donor hearts

Intervention

CaMKII genetic manipulation (DKO or transgenic overexpression) and in vitro CaMKII administration

Comparator

Wild-type (WT) mice and nonfailing human donor hearts

Outcome

Titin phosphorylation and cardiomyocyte passive force (F(passive))surrogate

CaMKII phosphorylates titin at conserved sites to lower passive force, a mechanism that is deranged in heart failure and contributes to altered diastolic stress.

Cite This Study

Hamdani et al. (2013) studied this question.

synapsesocial.com/papers/69fe008f015782f43c50db4d https://doi.org/10.1161/circresaha.111.300105

Topics

Heart failure HFrEF treatment

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Crucial Role for Ca ²⁺ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Crucial Role for Ca ²⁺ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider