Comparative analysis demonstrates phosphothreonine recognition by FHA domains across eukaryotes and bacteria, suggesting an ancient regulatory mechanism for protein complex assembly.
The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism.
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Durocher et al. (2001) studied this question.
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