In vitro study reveals verapamil reduces bedaquiline and clofazimine MICs in clinical Mycobacterium tuberculosis isolates, indicating efflux acts as a targetable resistance mechanism.
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.
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Gupta et al. (2013) studied this question.
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