What is the clinical evidence from this study?

Study design: Cohort. Population: Patients undergoing elective coronary angioplasty (n=120). Intervention: Insufficient collateral blood flow (≤23%) vs. Sufficient collateral blood flow (>24%). Primary outcome: Ischemic events (p=<0.05).

What question did this study set out to answer?

To evaluate a pressure-derived equation for calculating recruitable coronary collateral blood flow during coronary artery occlusion and examine its ability to predict future ischemic events.

May 8, 2026Journal of the American College of Cardiology

Quantification of recruitable coronary collateral blood flow in conscious humans and its potential to predict future ischemic events

Q: What are the key findings of this study?

Insufficient collateral blood flow (≤23%) during coronary angioplasty was significantly associated with future ischemic events, accounting for 15 of 16 events during follow-up (p<0.05).

Q: What question did this study set out to answer?

To evaluate a pressure-derived equation for calculating recruitable coronary collateral blood flow during coronary artery occlusion and examine its ability to predict future ischemic events.

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Key result

Low collateral flow during angioplasty is linked to future ischemic events, accounting for 15 of 16.

P<0.05
n=120

Why the study?

A quantitative method to calculate recruitable collateral blood flow at coronary artery occlusion in conscious patients and its predictive value for future ischemic events was not established.

Does pressure-derived fractional collateral blood flow predict ischemia during balloon occlusion and future ischemic events in patients undergoing elective coronary angioplasty?

Key Points

To evaluate a pressure-derived equation for calculating recruitable coronary collateral blood flow during coronary artery occlusion and examine its ability to predict future ischemic events.
Assessed 120 patients undergoing elective coronary angioplasty with recent positive exercise ECG findings.
Measured mean arterial, coronary wedge, and central venous pressures during 2-minute balloon inflations to calculate fractional collateral flow via (wedge pressure - central venous pressure) / (mean arterial pressure - central venous pressure).
Monitored patients for subsequent ischemic events across a follow-up period of 6 to 22 months.
Ischemia occurred during balloon inflation in 90 of 120 patients (82 of whom had fractional collateral flow ≤23%), whereas all 29 patients without ischemia had flow >24%.
During 6 to 22 months of follow-up, 16 patients developed an ischemic event, with 15 of the 16 cases occurring in the insufficient collateral flow group (p < 0.05).

Study Design

Type

Cohort (n=120)

Structured PICO

Does pressure-derived fractional collateral blood flow predict ischemia during balloon occlusion and future ischemic events in patients undergoing elective coronary angioplasty?

Population

120 patients undergoing elective coronary angioplasty with a recent positive exercise ECG, followed for 6 to 22 months.

Exposure

Calculation of pressure-derived fractional collateral blood flow (coronary wedge pressure minus central venous pressure divided by mean arterial pressure minus central venous pressure) during 2-minute balloon inflations

Outcome

Presence or absence of ischemia at balloon inflation and future ischemic eventssurrogate

Main Result

p-value: p=<0.05

Discussion

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Implication

Pressure-derived fractional collateral blood flow measured during coronary angioplasty can reliably distinguish sufficient from insufficient collateral circulation and predict future ischemic events.

Cite This Study

Pijls et al. (1995) conducted a cohort in Patients undergoing elective coronary angioplasty (n=120). Insufficient collateral blood flow (≤23%) vs. Sufficient collateral blood flow (>24%) was evaluated on Ischemic events (p=<0.05). Insufficient collateral blood flow (≤23%) during coronary angioplasty was significantly associated with future ischemic events, accounting for 15 of 16 events during follow-up (p<0.05).

synapsesocial.com/papers/69fe5344cc8253dea178c5ab https://doi.org/10.1016/0735-1097(95)00111-g

Topics

Women and heart disease

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Implication

Pressure-derived fractional collateral blood flow measured during coronary angioplasty can reliably distinguish sufficient from insufficient collateral circulation and predict future ischemic events.

Quantification of recruitable coronary collateral blood flow in conscious humans and its potential to predict future ischemic events

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Quantification of recruitable coronary collateral blood flow in conscious humans and its potential to predict future ischemic events

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider