Are resting physiological indexes (iFR, RFR, dPR) associated with the risk of 2-year vessel-oriented composite outcomes in deferred vessels of patients with coronary artery disease?
Resting pressure-derived physiological indexes (iFR, RFR, and dPR) are significantly associated with 2-year clinical outcomes and can be used to guide treatment strategies in coronary artery disease.
BACKGROUND: N-ammonia positron emission tomography, the changes in those indexes according to basal and hyperemic stenosis resistance and absolute hyperemic myocardial blood flow were compared. The association between resting physiological indexes and the risk of 2-year vessel-oriented composite outcomes (a composite of cardiac death, vessel-related myocardial infarction, and vessel-related ischemia-driven revascularization) was analyzed among 864 deferred vessels. RESULTS: N-ammonia positron emission tomography. All resting physiological indexes showed significant association with the risk of 2-year vessel-oriented composite outcomes (iFR per 0.1 increase: hazard ratio, 0.514 95% CI, 0.370-0.715, P<0.001; RFR per 0.1 increase: hazard ratio, 0.524 95% CI, 0.378-0.725, P<0.001; dPR per 0.1 increase: hazard ratio, 0.587 95% CI, 0.436-0.791, P<0.001) in deferred vessels. CONCLUSIONS: All resting pressure-derived physiological indexes (iFR, RFR, and dPR) can be used as invasive tools to guide treatment strategy in patients with coronary artery disease. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01621438.
Lee et al. (Thu,) studied this question.