Population
Rats with myocardial infarction (n=24) and sham-operated rats (n=22)
Comparison
Heart failure secondary to myocardial infarction vs Sham-operated rats
Design
Preclinical
Authors
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Implicates reduced pulmonary ET-1 clearance in post-MI HF; leaves open translation to human pathophysiology or therapy.
Heart failure following myocardial infarction reduces pulmonary clearance of endothelin-1, contributing to elevated circulating ET-1 levels.
Dupuis et al. (1998) studied this question.
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