Population
Guinea pig or rat isolated lungs, perfused mesentery of the rat, and in vivo rat models
Design
Preclinical
Authors
Loading...
Should not alter hypertension management; leaves open endothelin modulation for human validation.
Endothelin functions primarily as a local rather than circulating pressor hormone due to rapid pulmonary clearance and compensatory release of vasodilators.
Nucci et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: