Integrated cardiac, renal, and endocrine actions of endothelin.
Why the study?
Does intravenous infusion of endothelin affect cardiovascular, renal, and endocrine function in anesthetized dogs?
Population
anesthetized dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Endothelin may drive vasoconstriction and renal impairment; leaves open its role in human cardiorenal disease.
Structured PICO
Does intravenous infusion of endothelin affect cardiovascular, renal, and endocrine function in anesthetized dogs?
P
Population
anesthetized dogs
I
Intervention
Intravenous infusion of endothelin (50 ng/kg per min)
O
Outcome
cardiovascular-renal and endocrine function (arterial pressure, vascular resistance, cardiac output, renal blood flow, glomerular filtration rate, sodium excretion, plasma renin activity, atrial natriuretic factor, vasopressin, and aldosterone)surrogate
Endothelin acts as a potent vasoconstrictor in vivo, elevating systemic blood pressure while markedly decreasing cardiovascular and renal function.
Cite This Study
Miller et al. (1989) studied this question.