What question did this study set out to answer?

To determine the role of sodium intake in blood pressure regulation among obese adolescents and assess whether weight loss diminishes sodium sensitivity.

August 31, 1989New England Journal of Medicine

The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents

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To determine the role of sodium intake in blood pressure regulation among obese adolescents and assess whether weight loss diminishes sodium sensitivity.
Measured mean arterial pressure in 60 obese and 18 nonobese adolescents following sequential 2-week periods of high-salt (>250 mmol/day) and low-salt (<30 mmol/day) diets.
Evaluated 51 of the obese adolescents on the same dietary regimens before and after completion of a 20-week weight-loss program.
Changing from high to low sodium decreased mean arterial pressure by -12 ± 1 mm Hg in obese adolescents versus +1 ± 2 mm Hg in nonobese controls (P < 0.001).
Sodium sensitivity was best predicted by fasting plasma insulin, low-salt plasma aldosterone, high-salt plasma norepinephrine, and percentage of body fat.
Among 36 obese adolescents who lost >1 kg, blood pressure sensitivity to sodium dropped to -1 ± 1 mm Hg, whereas 15 adolescents without weight loss remained sensitive (-11 ± 3 mm Hg).

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Implication

Interventional dietary study demonstrates that weight reduction normalizes sodium-sensitive blood pressure in obese adolescents, highlighting endocrine drivers of salt-induced hypertension.

Cite This Study

Rocchini et al. (1989) studied this question.

synapsesocial.com/papers/69fe7990d8476229fea3593d https://doi.org/10.1056/nejm198908313210905

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Implication

Interventional dietary study demonstrates that weight reduction normalizes sodium-sensitive blood pressure in obese adolescents, highlighting endocrine drivers of salt-induced hypertension.

The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents

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Discussion

Implication

Cite This Study

The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents

Key Points

Discussion

Implication

Cite This Study

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