April 4, 2006Circulation

Evidence of a Dominant Backward-Propagating “Suction” Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy

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Structured PICO

Population

20 subjects after a normal coronary arteriogram

Intervention

Simultaneous pressure and Doppler velocity measurement with intracoronary wires in the left main stem, left anterior descending, and circumflex arteries, analyzed using wave intensity analysis

Comparator

Subjects with left ventricular hypertrophy (LVH) compared to normal subjects

Outcome

Identification and quantification of individual pressure and velocity waves within the coronary artery circulationsurrogate

Diastolic coronary blood flow is predominantly driven by a backward-traveling suction wave generated by myocardial microcirculatory decompression, which is significantly attenuated in patients with left ventricular hypertrophy.

Discussion

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Implication

Attenuated suction wave in LVH may impair diastolic coronary perfusion; hypothesis-generating for wave-intensity studies in hypertrophy.

Cite This Study

Davies et al. (2006) studied this question.

synapsesocial.com/papers/69fe79a8d8476229fea3597c https://doi.org/10.1161/circulationaha.105.603050

Topics

Echocardiography

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Evidence of a Dominant Backward-Propagating “Suction” Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Evidence of a Dominant Backward-Propagating “Suction” Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider