Why the study?
Does the administration of vasoactive agents (nitroglycerin and ergonovine) alter the ischemic threshold in patients with stable angina and single-vessel total occlusion?
Does the administration of vasoactive agents (nitroglycerin and ergonovine) alter the ischemic threshold in patients with stable angina and single-vessel total occlusion?
Constriction of distal coronary arteries or collateral vessels may cause myocardial ischemia in patients with chronic stable angina, explaining the variable ischemic threshold.
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Supports distal constriction modulating ischemia in total occlusion; hypothesis-generating and requires prospective validation before clinical consideration.
Pupita et al. (1990) studied this question.
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