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Should not yet change VF prevention strategies; leaves open prospective validation of restitution-targeted therapies.
Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.
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Weiss et al. (2000) studied this question.
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