Key result
Two-variable model equations of cardiac tissue demonstrate that an oscillatory pulse instability causes action potential duration alternation in 1D and spontaneous spiral breakup in 2D.
Introduces a two-variable model that reproduces oscillatory pulse instability and demonstrates how it leads to spontaneous spiral breakup and disorganized electrical wave activity in cardiac tissue.
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May inform mechanistic arrhythmia modeling; leaves open translation to human tissue without validation.
Two-variable model equations that capture some essential dynamical features of quantitative electrophysiological models of cardiac tissue are introduced. In one dimension, these equations naturally reproduce an experimentally observed oscillatory pulse instability that causes an alternation in action potential duration. In two dimensions, spontaneous spiral breakup leading to a spatially disorganized electrical wave activity is shown to occur as a direct consequence of this instability.
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Alain Karma (1993) studied Action potential propagation in cardiac tissue. Two-variable model equations was evaluated on Spontaneous spiral breakup and spatially disorganized electrical wave activity. Two-variable model equations of cardiac tissue demonstrate that an oscillatory pulse instability causes action potential duration alternation in 1D and spontaneous spiral breakup in 2D.
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