Key result
Greater dynamic instability in simulated tissue markedly lowers the refractoriness dispersion required for wave break.
Why the study?
The interaction between dynamic factors and fixed electrophysiological heterogeneity in promoting wave break in cardiac tissue was not well understood.
Population
Simulated two-dimensional cardiac tissue using the Luo-Rudy (LR1) ventricular action potential model
Comparison
Varying maximal amplitude of slow inward Ca(2+) current and random action potential duration dispersion vs homogeneous tissue
Design
Simulation study using computational modeling
Authors
Loading...
Supports targeting dynamic instability to prevent wave break in models; leaves open clinical translation to antiarrhythmic strategies.
Reducing the dynamic instability of cardiac cells, such as by decreasing the steepness of action potential duration restitution, may be a viable antifibrillatory strategy.
Xie et al. (2001) studied Cardiac fibrillation. Dynamic instability and fixed electrophysiological heterogeneity was evaluated on Wave break induction. In simulated cardiac tissue, the degree of dispersion of refractoriness required to induce wave break decreased markedly as dynamic instability of the cardiac model increased.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: