Population
Two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 ventricular action potential model
Design
Preclinical
Authors
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APD gradients may promote spiral wave drift in heterogeneous tissue; leaves open mechanistic relevance to clinical reentry.
Computer simulations demonstrate that gradients of action potential duration cause spiral wave drift, providing insights into the dynamics of cardiac arrhythmias in heterogeneous tissue.
Tusscher et al. (2003) studied this question.
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