August 30, 2002Chaos An Interdisciplinary Journal of Nonlinear ScienceOpen Access

Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity

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Population

Simplified ionic model of the cardiac action potential fitted to mesoscopic characteristics of cardiac tissue

Design

Preclinical

Discussion

Member takes

Implication

Unifies spiral wave breakup mechanisms in one model; hypothesis-generating for antiarrhythmic targets with no clinical translation yet.

Structured PICO

Population

Simplified ionic model of the cardiac action potential (3V-SIM) fitted to mesoscopic characteristics of cardiac tissue

Intervention

Simulation of different parameter regimes and physiological properties (e.g., high or low excitability, spiral tip trajectory types, and tissue structures such as rotational anisotropy and periodic boundary conditions)

Outcome

Mechanisms of spiral wave breakup

A single simplified ionic model can reproduce multiple mechanisms of spiral wave breakup, demonstrating that these are not model-specific phenomena and providing insights for antiarrhythmic drug design.

Cite This Study

A 2002 study studied this question.

synapsesocial.com/papers/6a7da54d14e877b18fa14134 https://doi.org/10.1063/1.1504242

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Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider