Population
Simulated cardiac tissue (two-dimensional sheet) using the Luo-Rudy ventricular action potential model
Design
Preclinical
Authors
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May guide restitution-targeted antiarrhythmic development; leaves open in vivo human validation.
Simulation data suggest that targeting both action potential duration and conduction velocity restitution properties may be an effective strategy for developing novel antiarrhythmic drugs to prevent ventricular fibrillation.
Qu et al. (1999) studied this question.
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