Key result
In simulated two-dimensional cardiac tissue, the vulnerable window for re-entry is determined by tissue heterogeneity and electrical restitution properties, with steeper APD restitution reducing it.
This computational study demonstrates that electrical restitution properties and tissue heterogeneity critically determine the vulnerable window for re-entrant arrhythmias.
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Simulations identify re-entry determinants but should not alter practice; leaves open validation and therapeutic targeting in patients.
Tran et al. (2007) studied Ventricular fibrillation. Premature extrastimuli and electrical restitution properties was evaluated on Vulnerable window of re-entry. In simulated two-dimensional cardiac tissue, the vulnerable window for re-entry is determined by tissue heterogeneity and electrical restitution properties, with steeper APD restitution reducing it.
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