Population
Simulated 150 x 150 mm 2D sheet of isotropic cardiac ventricular tissue using a simplified computational model
Design
Preclinical
Authors
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Regional APD heterogeneity may promote re-entry after premature stimuli in tissue models; hypothesis-generating for clinical substrates and requires intact-heart validation.
Regional differences in APD restitution provide an arrhythmogenic substrate that can initiate wavebreak and re-entry following premature stimuli, independent of the steepness of the APD restitution curve.
Clayton et al. (2005) studied this question.
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