Key result
Premature stimuli caused biphasic modulation of action potential duration dispersion in intact guinea pig hearts, decreasing from 70 +/- 29 ms2 to 10 +/- 7 ms2 before increasing to 66 +/- 25 ms2.
Population
Intact guinea pig hearts (n = 15)
Comparison
Single premature stimuli introduced at… vs Steady state baseline pacing
Design
Preclinical
Authors
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Provides mechanistic insight into repolarization in guinea pigs; leaves open applicability to human arrhythmia risk.
A single premature stimulus profoundly alters the pattern and synchronization of ventricular repolarization due to heterogeneous cellular restitution kinetics, providing mechanistic insights into arrhythmia initiation.
Laurita et al. (1996) studied Ventricular repolarization (n=15). Premature stimulus vs. Baseline pacing was evaluated on Action potential duration (APD) dispersion. Premature stimuli caused biphasic modulation of action potential duration dispersion in intact guinea pig hearts, decreasing from 70 +/- 29 ms2 to 10 +/- 7 ms2 before increasing to 66 +/- 25 ms2.
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