Key result
Apical pacing at higher frequencies shortens V-ERP and MAP duration, displacing electrical restitution curves downward.
Why the study?
The influence of heart rate on electrical restitution and conduction intervals of ventricular premature beats in patients with coronary artery disease was not well characterized.
Does heart rate influence electrical restitution and conduction intervals of ventricular premature beats in patients with coronary artery disease?
Population
20 patients with coronary artery disease
Comparison
Electrical restitution and conduction intervals at basic paced cycle lengths of 700, 600, and 500 msec
Design
Electrophysiological study with apical pacing and interpolation of extrasystoles
Authors
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Faster apical pacing may alter arrhythmia vulnerability in CAD; leaves open effects on programmed stimulation protocols.
Does heart rate influence electrical restitution and conduction intervals of ventricular premature beats in patients with coronary artery disease?
p-value: p=<0.001
The time course of electrical restitution and intraventricular conduction intervals are significantly modified by basic cycle length and coupling intervals in human ventricles, which has implications for programmed stimulation protocols.
Endresen et al. (1989) studied Coronary artery disease (n=20). Apical pacing with interpolation of extrasystoles vs. Steady-state beats and lower heart rates was evaluated on Ventricular effective refractory periods (V-ERP), duration of monophasic action potentials (MAPs), and electrical restitution curves (p=<0.001). Apical pacing at higher frequencies shortened ventricular effective refractory periods and monophasic action potential duration, displacing electrical restitution curves downwards (P<0.001).
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