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May 1, 1981The Journal of PhysiologyOpen Access

The action‐potential duration and contractile response of the intact heart related to the preceding interval and the preceding beat in the dog and cat

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Population

Anaesthetized dogs and isolated ejecting cat hearts

Comparison

Variable pacing intervals, frequencies, paired… vs Control period of steady pacing

Design

Preclinical

Authors

GEG. ElzingaMLMax J. LabMNMark I. M. Noble

Discussion

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Overview

Electrical and mechanical restitution in the intact heart appear to occur through separate processes, with electrical restitution depending on membrane conductances and mechanical on intracellular calcium availability.

Structured PICO

P
Population
Anaesthetized dogs and isolated ejecting cat hearts
I
Intervention
Variable pacing intervals (test-pulse intervals), frequencies, paired pulse stimulation, and adrenaline administration
C
Comparator
Control period of steady pacing
O
Outcome
Action potential duration (measured at 70% repolarization) and maximum rate of rise of left ventricular pressure (dP(lv)/dt(max))surrogate

Electrical and mechanical restitution in the intact heart appear to occur through separate processes, with electrical restitution depending on membrane conductances and mechanical on intracellular calcium availability.

Cite This Study

Elzinga et al. (1981) studied this question.

synapsesocial.com/papers/6a8c435790fae8fd47e9b634https://doi.org/10.1113/jphysiol.1981.sp013720
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