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December 1, 1983The Journal of PhysiologyOpen Access

Cardiac action potential duration and contractility in the intact dog heart.

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Population

Closed-chest anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade

Design

Preclinical

Authors

ADA. J. Drake‐HollandMNMark I. M. NobleMPMATTIE G.C. PIETERSE

Discussion

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Overview

In an intact dog heart model, action potential duration influences the amount of contraction activator entering the intracellular store, which becomes available for release upon the next depolarization.

Structured PICO

P
Population
Closed-chest anaesthetized dogs with atrioventricular dissociation and beta-adrenergic blockade
I
Intervention
Right ventricular stimulation with protocols consisting of a conditioning 'priming' period and a test period with varying intervals
O
Outcome
Relationship between maximum rate of rise of left ventricular pressure (DP) and action potential duration (a.p.d.)surrogate

In an intact dog heart model, action potential duration influences the amount of contraction activator entering the intracellular store, which becomes available for release upon the next depolarization.

Cite This Study

Drake‐Holland et al. (1983) studied this question.

synapsesocial.com/papers/6a7c7ac1bb130b2209fd654dhttps://doi.org/10.1113/jphysiol.1983.sp014966
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