Population
Intact closed-chest anaesthetized dogs with complete atrioventricular dissociation and beta-adrenergic…
Design
Preclinical
Key result
In intact dogs, there was no consistent relationship between action potential duration and contractility, suggesting repolarization is not controlled by activator calcium responsible for contractility.
Authors
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No consistent APD-contractility link in intact dogs; leaves open frequency-dependent repolarization control independent of activator calcium.
In an intact dog heart model, action potential duration shortening with increased frequency is related to the frequency change itself rather than being controlled by activator calcium responsible for contractility.
Drake et al. (1982) studied Complete atrioventricular dissociation and beta-adrenergic blockade (animal model). Various potentiating stimulus trains (frequency potentiation, post-extrasystolic potentiation, paired pulse stimulation) was evaluated on Relationship between action potential duration and contractility. In intact dogs, there was no consistent relationship between action potential duration and contractility, suggesting repolarization is not controlled by activator calcium responsible for contractility.
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