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May 1, 1984The Journal of PhysiologyOpen Access

Changes in the electrical activity of dog cardiac Purkinje fibres at high heart rates.

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Why the study?

Does high rate stimulation alter the electrical activity and background currents in dog cardiac Purkinje fibres?

Population

Dog cardiac Purkinje fibres

Comparison

High rates of stimulation vs Baseline/lower rates of stimulation

Design

Preclinical

Authors

MBMark R. BoyettDFDavid Fedida

Discussion

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Overview

High-rate effects in canine Purkinje fibers should not yet guide clinical pacing; leaves open Na-K pump contributions to rate-dependent repolarization.

Structured PICO

Does high rate stimulation alter the electrical activity and background currents in dog cardiac Purkinje fibres?

P
Population
Dog cardiac Purkinje fibres
I
Intervention
High rates of stimulation (increased stimulus frequency)
C
Comparator
Baseline/lower rates of stimulation
O
Outcome
Changes in electrical activity (rate of repolarization, action potential duration, maximum diastolic potential, pace-maker potential amplitude, background current)surrogate

High stimulation rates in dog Purkinje fibers cause slow changes in electrical activity, including action potential shortening and increased maximum diastolic potential, primarily due to increased electrogenic Na-K-pump activity.

Cite This Study

Boyett et al. (1984) studied this question.

synapsesocial.com/papers/6a1feb1ff35583189204ae66https://doi.org/10.1113/jphysiol.1984.sp015206
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in Left Ventricular Repolarization and Ion Channel Currents Following a Transient Rate Increase Superimposed on Bradycardia in Anesthetized Dogs2000 · 31 citations
  2. 2Direct measurement of changes in sodium pump current in canine cardiac Purkinje fibers1979 · 91 citations
  3. 3Electrophysiological mechanisms underlying rate-dependent changes of refractoriness in normal and segmentally depressed canine Purkinje fibers. The characteristics of post-repolarization refractoriness.1986 · 61 citations
  4. 4Effects of stimulation frequency on potassium activity and cell volume in cardiac tissue1981 · 97 citations
  5. 5Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range2003 · 32 citations