July 1, 1980Proceedings of the National Academy of SciencesOpen Access

Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers.

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Population

Small voltage-clamped canine cardiac Purkinje fibers

Design

Preclinical

Authors

DGDavid C. GadsbySemmelweis University

Discussion

Member takes

Implication

Should not yet inform clinical potassium targets; leaves open translation of pump kinetics to human arrhythmogenesis.

Structured PICO

Population

Small voltage-clamped canine cardiac Purkinje fibers

Intervention

Brief exposure to K+-free fluid to temporarily inhibit the sodium pump, followed by sudden return to K+-containing fluid

Outcome

Transient increments in sodium pump current (exponential time course of decay and peak amplitude)surrogate

This preclinical study demonstrates that the sodium pump in canine cardiac Purkinje fibers is half-maximally activated by ~1 mM extracellular K+ and operates with a constant Na+/K+ coupling ratio.

Cite This Study

David C. Gadsby (1980) studied this question.

synapsesocial.com/papers/6a6fbd73b27f15817827144a https://doi.org/10.1073/pnas.77.7.4035

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Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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