Key result
The apparent affinity of the Na+-K+ pump towards K+ in cardiac Purkinje cells depends on both the membrane potential and the extracellular Na+ concentration.
Population
Isolated, single Purkinje cells of the rabbit heart
Design
Preclinical
Authors
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Caution against clinical translation from rabbit Purkinje cells; leaves open voltage-dependent pump kinetics for human modeling.
In rabbit cardiac Purkinje cells, the Na+-K+ pump's affinity for K+ depends on membrane potential and extracellular Na+ concentration, indicating multiple voltage-sensitive steps in the pump cycle.
Bielen et al. (1991) studied this question. Membrane potential and extracellular monovalent cations was evaluated on Na+ pump current (Ip). The apparent affinity of the Na+-K+ pump towards K+ in cardiac Purkinje cells depends on both the membrane potential and the extracellular Na+ concentration.
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