Why the study?
Does temporary stimulation of the sodium pump in canine cardiac Purkinje fibers produce electrophysiological effects consistent with an increase in outward pump current rather than extracellular K depletion?
Population
Thin canine cardiac Purkinje fibers
Comparison
Exposure to K-free fluid for 15 s to 6 min to… vs Expected effects of extracellular K depletion
Design
Preclinical
Authors
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Distinguishes pump current from K depletion in canine Purkinje fibers; leaves open translation to human electrophysiology.
Does temporary stimulation of the sodium pump in canine cardiac Purkinje fibers produce electrophysiological effects consistent with an increase in outward pump current rather than extracellular K depletion?
Temporary stimulation of the sodium pump in canine cardiac Purkinje fibers produces electrophysiological effects consistent with a transient increase in outward pump current rather than extracellular potassium depletion.
Gadsby et al. (1979) studied this question.
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