Key result
Propagated action potentials can be obtained in canine cardiac Purkinje fibers exposed to sodium-free, calcium-rich solutions, with the magnitude of overshoot varying with extracellular calcium.
Canine cardiac Purkinje fibers can generate calcium-dependent propagated action potentials in sodium-free solutions, which are abolished by calcium channel blockers but unaffected by tetrodotoxin.
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Calcium-dependent Purkinje conduction demonstrated in vitro; leaves open in vivo relevance and human translation.
Aronson et al. (1973) studied Canine cardiac Purkinje fibers. Sodium-free, calcium-rich solutions was evaluated on Electrical activity characteristics (maximum diastolic potential, overshoot, upstroke velocity, conduction velocity, action potential duration). Propagated action potentials can be obtained in canine cardiac Purkinje fibers exposed to sodium-free, calcium-rich solutions, with the magnitude of overshoot varying with extracellular calcium.
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