Population
Purkinje fibers excised from the left ventricle of the dog heart
Comparison
Alteration of membrane potential using partition… vs Baseline conditions / normal Tyrode solution
Design
Preclinical
Authors
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Distinguishes ionic bases of abnormal vs normal automaticity in Purkinje fibers; leaves open translation to human arrhythmias.
In canine Purkinje fibers, low-voltage oscillations are calcium-dependent, suggesting the involvement of a slow channel activated at around -50mV.
Sunao Imanishi (1971) studied this question.
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