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February 14, 2003The Journal of PhysiologyOpen Access

Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range

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Population

Canine cardiac single Purkinje cells

Comparison

Whole-cell patch-clamp analysis with… vs Control conditions

Design

Preclinical

Authors

MRMarcello RotaHeart Failure & TransplantMVMario VassalleState University of New York

Discussion

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Implication

Hypothesis-generating for Purkinje automaticity mechanisms; leaves open human relevance and therapeutic potential.

Structured PICO

P
Population
Canine cardiac single Purkinje cells
I
Intervention
Whole-cell patch-clamp analysis with pharmacological agents (tetrodotoxin 15 μm, lidocaine 100 μm, Cs+ 2 mm, Ba2+ 2 mm) and varying extracellular potassium concentrations
C
Comparator
Control conditions (absence of blockers, standard extracellular potassium)
O
Outcome
Electrophysiological characterization of a slowly inactivating Na(+) current (I(Na3)) and its role in spontaneous dischargesurrogate

Identifies a novel, slowly inactivating sodium current (I(Na3)) in canine Purkinje cells that plays a role in cardiac pacemaker activity.

Cite This Study

Rota et al. (2003) studied this question.

synapsesocial.com/papers/6a2253453dc1edca6bb6004chttps://doi.org/10.1113/jphysiol.2003.039263
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of a TTX-sensitive Na+ current in pacemaker cells isolated from rabbit sinoatrial node1996 · 58 citations
  2. 2Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.1992 · 69 citations
  3. 3Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells2001 · 117 citations
  4. 4The pacemaker current in cardiac Purkinje myocytes.1995 · 47 citations
  5. 5Na+ current contribution to the diastolic depolarization in newborn rabbit SA node cells2000 · 47 citations