What does this research mean for the field?

Slow and incomplete inactivation of sodium conductance, along with inward calcium currents, are key mechanisms maintaining the plateau phase of the action potential in cardiac Purkinje fibres. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

July 1, 1968The Journal of PhysiologyOpen Access

Slow inactivation of currents in cardiac Purkinje fibres

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Population

cardiac Purkinje fibres

Design

Preclinical

Authors

HRH. RéuterUniversity of Cologne

Discussion

Member takes

Implication

May refine models of Purkinje plateau currents; leaves open translation to human myocardium.

Structured PICO

Population

cardiac Purkinje fibres

Intervention

depolarizing voltage clamp steps and varying ionic solutions (Na-containing vs Na-free)

Outcome

membrane currents (inward and outward tails, sodium, chloride, and calcium currents)surrogate

This basic electrophysiology study demonstrates that slow inactivation of sodium and calcium currents contributes significantly to the plateau phase of the cardiac action potential in Purkinje fibers.

Cite This Study

H. Réuter (1968) studied this question.

synapsesocial.com/papers/6a1ba529ab6181c407abb12e https://doi.org/10.1113/jphysiol.1968.sp008557

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Bookmark

Slow inactivation of currents in cardiac Purkinje fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Slow inactivation of currents in cardiac Purkinje fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider