PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
June 1, 2000Journal of Cardiovascular Electrophysiology

Changes in Left Ventricular Repolarization and Ion Channel Currents Following a Transient Rate Increase Superimposed on Bradycardia in Anesthetized Dogs

View Full Paper
Ask AI
Bookmark
Share

Population

Single mid-myocardial left ventricular myocytes from anesthetized dogs with 1 week of complete AV block

Comparison

1 hour of left ventricular pacing at 120 beats/min vs No pacing

Design

Preclinical

Authors

MRMichael RubartJLJohn C. LopshireNFNaomi S. Fineberg

Discussion

Loading...

Member takes

Overview

Extends rate-dependent refractoriness mechanisms in canine models; leaves open translation to human pacing strategies.

Structured PICO

P
Population
Single mid-myocardial left ventricular myocytes from anesthetized dogs with 1 week of complete AV block
I
Intervention
1 hour of left ventricular pacing at 120 beats/min
C
Comparator
No pacing
O
Outcome
Changes in transmembrane voltages and currents (action potential duration, Ito, I(Ca.L), I(Cl.Ca))surrogate

A transient rate increase superimposed on bradycardia in dogs prolongs ventricular refractoriness via frequency-dependent reduction in Ito and enhanced I(Ca.L).

Cite This Study

Rubart et al. (2000) studied this question.

synapsesocial.com/papers/6a7794ccf6749a0058ec66ddhttps://doi.org/10.1111/j.1540-8167.2000.tb00028.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rapid Rates During Bradycardia Prolong Ventricular Refractoriness and Facilitate Ventricular Tachycardia Induction With Cesium in Dogs1996 · 59 citations
  2. 2Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation1997 · 818 citations
  3. 3Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure1996 · 577 citations
  4. 4Changes in the electrical activity of dog cardiac Purkinje fibres at high heart rates.1984 · 76 citations
  5. 5Tachycardia-Induced Changes in Na<sup>+</sup>Current in a Chronic Dog Model of Atrial Fibrillation1997 · 257 citations