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July 15, 1996Circulation59 citations

Rapid Rates During Bradycardia Prolong Ventricular Refractoriness and Facilitate Ventricular Tachycardia Induction With Cesium in Dogs

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Why the study?

Does rapid ventricular pacing superimposed on bradycardia prolong ventricular refractoriness and facilitate VT induction with cesium in dogs?

Population

Anesthetized closed-chest dogs with AV block produced by radiofrequency catheter ablation

Comparison

Rapid left ventricular pacing followed by… vs Uninterrupted AV block followed by incremental…

Design

Preclinical

Authors

TSTadashi SatohDZDouglas P. Zipes

Discussion

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Overview

Transient rapid pacing superimposed on bradycardia prolongs ventricular refractoriness and facilitates the induction of ventricular tachycardia in a canine model.

Structured PICO

Does rapid ventricular pacing superimposed on bradycardia prolong ventricular refractoriness and facilitate VT induction with cesium in dogs?

P
Population
Anesthetized closed-chest dogs with AV block produced by radiofrequency catheter ablation
I
Intervention
Rapid left ventricular pacing (PCL = 500 or 250 ms for 1 hour or 30 minutes) followed by incremental doses of CsCl
C
Comparator
Uninterrupted AV block (no rapid pacing) followed by incremental doses of CsCl
O
Outcome
Ventricular effective refractory period (V-ERP), QT interval, early afterdepolarizations, and prevalence of ventricular tachycardiasurrogate

Transient rapid pacing superimposed on bradycardia prolongs ventricular refractoriness and facilitates the induction of ventricular tachycardia in a canine model.

Cite This Study

Satoh et al. (1996) studied this question.

synapsesocial.com/papers/6a77f3c1d8eb58afc2be4279https://doi.org/10.1161/01.cir.94.2.217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in Left Ventricular Repolarization and Ion Channel Currents Following a Transient Rate Increase Superimposed on Bradycardia in Anesthetized Dogs2000 · 31 citations
  2. 2Short‐Term Rapid Ventricular Pacing Prolongs Ventricular Refractoriness in Patients1998 · 32 citations
  3. 3Programmed electrical stimulation and drugs identify two subgroups of ventricular tachycardias occurring 16-24 hours after occlusion of the left anterior descending artery.1992 · 2 citations
  4. 4Bradycardia-dependent triggered activity: relevance to drug-induced multiform ventricular tachycardia.1983 · 314 citations
  5. 5Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation1997 · 818 citations