Population
10 dogs undergoing computerized epicardial mapping, and computer simulation using the Luo-Rudy I ventricular…
Design
Preclinical
Authors
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Links restitution interactions to VF onset in animal models; leaves open human translation and therapeutic targeting.
This study demonstrates that the interaction of conduction velocity and effective refractory period restitutions drives the spatiotemporal oscillations and wavebreaks that initiate ventricular fibrillation during rapid pacing.
Cao et al. (1999) studied this question.
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