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February 1, 1992CirculationOpen Access

Programmed electrical stimulation and drugs identify two subgroups of ventricular tachycardias occurring 16-24 hours after occlusion of the left anterior descending artery.

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Population

21 conscious dogs with chronic atrioventricular block, 1 day after left anterior descending coronary artery…

Design

Preclinical

Authors

MVMarc A. VosAGAnton P.M. GorgelsJLJet D. M. Leunissen

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Overview

In a canine model of post-infarction VT, slower VTs are suppressible by pacing, lidocaine, and verapamil, whereas faster VTs are resistant to pacing and lidocaine, suggesting different underlying mechanisms of abnormal automaticity.

Structured PICO

P
Population
21 conscious dogs with chronic atrioventricular block, 1 day after left anterior descending (LAD) coronary artery occlusion, exhibiting 60 sustained ventricular tachycardias.
I
Intervention
Overdrive pacing (interstimulus intervals of 400, 300, and 200 msec for 15, 60, and 120 seconds) and antiarrhythmic drugs (lidocaine 3 mg/kg, verapamil 0.4-1.0 mg/kg, or flunarizine 2 mg/kg).
O
Outcome
Response to overdrive pacing (suppression) and effect of antiarrhythmic drugs on cycle length and termination of VT.surrogate

In a canine model of post-infarction VT, slower VTs are suppressible by pacing, lidocaine, and verapamil, whereas faster VTs are resistant to pacing and lidocaine, suggesting different underlying mechanisms of abnormal automaticity.

Cite This Study

Vos et al. (1992) studied this question.

synapsesocial.com/papers/6a79841ab008f0cadf322261https://doi.org/10.1161/01.cir.85.2.747
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