What is the clinical evidence from this study?

Study design: Other. Population: Ventricular fibrillation (n=12). Intervention: Tetrodotoxin and verapamil vs. Predrug control. Primary outcome: Maximum upstroke rate of depolarization (Vmax) (p=<0.05).

What does this research mean for the field?

Tetrodotoxin significantly reduces the maximum upstroke rate of depolarization (Vmax) during early ventricular fibrillation in dogs, demonstrating the active participation of fast sodium channels during the initial stages of the arrhythmia. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1992Circulation ResearchOpen Access

Existence of both fast and slow channel activity during the early stages of ventricular fibrillation.

Q: What are the key findings of this study?

Tetrodotoxin significantly reduced the maximum upstroke rate of depolarization (Vmax) during early ventricular fibrillation in dogs compared to predrug control (p<0.05).

Q: What does this research mean for the field?

Tetrodotoxin significantly reduces the maximum upstroke rate of depolarization (Vmax) during early ventricular fibrillation in dogs, demonstrating the active participation of fast sodium channels during the initial stages of the arrhythmia. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Tetrodotoxin significantly reduced the maximum upstroke rate of depolarization (Vmax) during early ventricular fibrillation in dogs compared to predrug control (p<0.05).

Population

12 open-chest dogs

Comparison

Superfusion with tetrodotoxin (low 2.8 x 10 M… vs Predrug ventricular fibrillation and successive…

Design

Preclinical

Follow-up

20 seconds of VF

Authors

XZXiaohong ZhouAstraZeneca (Italy)PGPaul A. GuseUniversity of Miami PWPatrick D. WolfPennsylvania State University

Discussion

Member takes

Implication

Indicates persistent fast sodium channel activity in early VF; leaves open relevance to human antiarrhythmic strategies.

Structured PICO

Population

12 open-chest dogs

Intervention

Superfusion with tetrodotoxin (TTX) (low 2.8 x 10(-5) M and high 10(-4) M concentrations) or verapamil (low 4 microM and high 100 microM concentrations) during electrically induced ventricular fibrillation

Comparator

Predrug ventricular fibrillation (control cycles before drug administration) and successive episodes of VF without drugs

Outcome

Maximum upstroke rate of depolarization of an action potential (Vmax) at the onset and after 5, 10, 15, and 20 seconds of ventricular fibrillationsurrogate

Main Result

p-value: p=<0.05

Both fast (sodium) and slow channel activity persist during the early stages (up to 20 seconds) of ventricular fibrillation in an open-chest dog model.

Cite This Study

Zhou et al. (1992) studied Ventricular fibrillation (n=12). Tetrodotoxin and verapamil vs. Predrug control was evaluated on Maximum upstroke rate of depolarization (Vmax) (p=<0.05). Tetrodotoxin significantly reduced the maximum upstroke rate of depolarization (Vmax) during early ventricular fibrillation in dogs compared to predrug control (p<0.05).

synapsesocial.com/papers/6a1709b2b082e78ad77bcd65 https://doi.org/10.1161/01.res.70.4.773

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Existence of both fast and slow channel activity during the early stages of ventricular fibrillation.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Existence of both fast and slow channel activity during the early stages of ventricular fibrillation.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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Also Consider