June 1, 1985CirculationOpen Access

An evaluation of automaticity and triggered activity in the canine heart one to four days after myocardial infarction.

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Population

Dogs with myocardial infarction induced by ligation of the left anterior descending coronary artery…

Comparison

Ventricular pacing, lidocaine, and ethmozin vs Baseline/control conditions

Design

Preclinical

Follow-up

1 to 4 days post-MI

Authors

HMH le MarecHôpital Laennec KDKenneth H. DangmanUConn Health PDPeter DaniloColumbia University

Discussion

Member takes

Implication

Ethmozin may suppress automatic post-MI VT in canines where lidocaine fails; leaves open mechanism and translation to human arrhythmias.

Structured PICO

Population

Dogs with myocardial infarction induced by ligation of the left anterior descending coronary artery (studied 1 to 4 days post-MI), including isolated subendocardial preparations and conscious dogs.

Intervention

Ventricular pacing (1 beat, 10 beats, or 1 min), lidocaine (2-10 micrograms/ml), and ethmozin (2-5 micrograms/ml)

Comparator

Baseline/control conditions

Outcome

Sustained rhythmic activity cycle length, overdrive suppression, and occurrence of delayed afterdepolarizationssurrogate

In a canine model of post-MI ventricular tachycardia, the predominant rhythm at 24 hours appears to be automatic rather than triggered, and is responsive to ethmozin but not lidocaine.

Cite This Study

Marec et al. (1985) studied this question.

synapsesocial.com/papers/6a72072e35aa2c282ce30dca https://doi.org/10.1161/01.cir.71.6.1224

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