Key result
Lidocaine facilitates inducible ventricular tachyarrhythmias in ~88% of dogs with chronic ischemic damage.
Why the study?
The arrhythmogenic effects of lidocaine in the presence of chronic myocardial ischemic injury were not well characterized.
Does lidocaine induce ventricular arrhythmias in a canine model of chronic myocardial ischemic damage?
Population
16 dogs 5 to 14 days after 90-min occlusion of left anterior descending coronary artery
Comparison
Lidocaine administration (3 mg/kg) vs baseline before lidocaine
Design
Preclinical experimental study
Authors
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May caution lidocaine use in chronic ischemia; leaves open translation to human arrhythmia risk.
Does lidocaine induce ventricular arrhythmias in a canine model of chronic myocardial ischemic damage?
Absolute Event Rate: 87.5% vs 0%
In a canine model of ischemic injury, lidocaine demonstrated arrhythmogenic properties by facilitating the induction of ventricular tachyarrhythmias and prolonging delayed electrical activity.
Patterson et al. (1982) studied Chronic Myocardial Ischemic Damage (n=16). Lidocaine vs. Baseline (before lidocaine administration) was evaluated on Induction of ventricular tachyarrhythmias by programmed electrical stimulation. Lidocaine administration facilitated the induction of ventricular tachyarrhythmias in 87.5% of dogs with chronic myocardial ischemic damage, compared to 0% before administration.