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July 1, 1972CirculationOpen Access

Effect of Lidocaine on the Ventricular Fibrillation Threshold in the Dog during Acute Ischemia and Premature Ventricular Contractions

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Why the study?

Does intravenous lidocaine increase the ventricular fibrillation threshold in anesthetized dogs during acute ischemia and premature ventricular contractions?

Population

Anesthetized open-chest dogs

Design

Preclinical

Authors

JSJoseph F. SpearUniversity of Oklahoma Health Sciences CenterGGGAIRY GERSTENBLITHHospital of the University of Pennsylvania

Discussion

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Implication

Supports hypothesis of lidocaine raising VF threshold in ischemia; requires human trials before any clinical consideration.

Structured PICO

Does intravenous lidocaine increase the ventricular fibrillation threshold in anesthetized dogs during acute ischemia and premature ventricular contractions?

P
Population
Anesthetized open-chest dogs
I
Intervention
Intravenous lidocaine (single injection of 0.7 mg/kg or loading injection of 2 mg/kg followed by 50-60-min constant drip of 70 µg/kg/min)
O
Outcome
Ventricular fibrillation threshold (minimum current in milliamperes required to induce ventricular fibrillation)surrogate

Intravenous lidocaine reduces the vulnerability to ventricular fibrillation during acute ischemia and premature ventricular contractions in a canine model.

Cite This Study

Spear et al. (1972) studied this question.

synapsesocial.com/papers/6a8a60155c716ca1a5d46d68https://doi.org/10.1161/01.cir.46.1.65
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrophysiological Actions of Lidocaine on Canine Ventricular Muscle and Purkinje Fibers1969 · 154 citations
  2. 2Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers1970 · 269 citations
  3. 3Ventricular Fibrillation Threshold (VFRT) in Experimental Coronary Occlusion : Comparative Studies on the Effect of G-I-K Solution and Some New Antiarrhythmic Agents1968 · 17 citations
  4. 4Fibrillation Threshold of Premature Ventricular Responses1966 · 144 citations