What question did this study set out to answer?

To evaluate the in vivo use-dependent conduction slowing and recovery dynamics of lidocaine in canine myocardium within the framework of the modulated receptor hypothesis.

July 1, 1986CirculationOpen Access

Use-dependent effects of lidocaine on conduction in canine myocardium: application of the modulated receptor hypothesis in vivo.

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Authors

JDJulia A DavisColorado State University TMTetsu MatsubaraAsahikawa Medical College Hospital MSMelvin M. ScheinmanElectrophysiology

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Implication

Extends modulated receptor hypothesis to in vivo canine conduction; leaves open human antiarrhythmic translation.

Key Points

To evaluate the in vivo use-dependent conduction slowing and recovery dynamics of lidocaine in canine myocardium within the framework of the modulated receptor hypothesis.
Measured His-to-ventricular conduction intervals as an index of conduction velocity in anesthetized dogs.
Assessed changes in conduction times during varying stimulation frequencies, premature extrastimuli pacing, and acute shifts in myocardial pH.
Conduction interval prolongation increased progressively with higher stimulation frequencies, reaching a new steady state within two to three depolarizations after frequency changes.
Conduction time following stimulation cessation shortened exponentially, demonstrating a terminal phase recovery time constant of 152 +/- 115 msec.
Lidocaine-induced conduction slowing was markedly enhanced during acidosis, an effect completely reversed after correcting pH.

Cite This Study

Davis et al. (1986) studied this question.

synapsesocial.com/papers/6a72c360fe4101aa97e0ef2e https://doi.org/10.1161/01.cir.74.1.205

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Use-dependent effects of lidocaine on conduction in canine myocardium: application of the modulated receptor hypothesis in vivo.

Discussion

Member takes

Implication

Key Points

Cite This Study

Use-dependent effects of lidocaine on conduction in canine myocardium: application of the modulated receptor hypothesis in vivo.

Discussion

Member takes

Implication

Key Points

Cite This Study

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