Key result
Lidocaine enhanced vagally-induced ventricular standstill by depressing idioventricular rhythm more than sinus rhythm, and depressed abnormal automaticity via fast sodium channel blockade.
Why the study?
Does lidocaine affect normal and abnormal cardiac pacemaker rhythms in canine cardiac tissues?
Population
Anaesthetized dogs and Purkinje fibres from hearts of the same animals
Comparison
Lidocaine vs Baseline/control conditions
Design
Preclinical
Authors
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May warrant caution in pacemaker-dependent patients; leaves open translation from canine models to clinical arrhythmia management.
Does lidocaine affect normal and abnormal cardiac pacemaker rhythms in canine cardiac tissues?
Lidocaine depresses normal and abnormal automaticity through direct and indirect effects of fast sodium channel blockade, with a more pronounced effect on idioventricular rhythm than sinus rhythm.
Abete et al. (1991) studied Normal and abnormal cardiac rhythms. Lidocaine was evaluated on Cardiac pacemaker rhythms including sino-atrial node rhythm, ventricular standstill, and idioventricular rhythm. Lidocaine enhanced vagally-induced ventricular standstill by depressing idioventricular rhythm more than sinus rhythm, and depressed abnormal automaticity via fast sodium channel blockade.
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