Key result
Lidocaine depressed Vmax and shortened action potential duration in Purkinje fibers from infarcted canine hearts, differing from its effects on normal hearts.
Population
Subendocardial Purkinje fibers from 24- to 72-hour-old myocardial infarcts in dogs, and normal canine hearts
Comparison
Lidocaine 2 X 10(-5) M vs Subendocardial Purkinje fibers in normal canine…
Design
Preclinical
Authors
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Differential lidocaine effects in infarcted tissue merit caution in ischemic settings; extends experimental data but leaves clinical translation open.
Lidocaine exerts differential electrophysiological effects on Purkinje fibers surviving in infarcted myocardium compared to normal tissue, notably depressing Vmax and shortening APD in infarcted fibers.
Allen et al. (1978) studied Myocardial infarction. Lidocaine vs. Normal hearts was evaluated on Transmembrane resting and action potentials (MDP, Vmax, APD). Lidocaine depressed Vmax and shortened action potential duration in Purkinje fibers from infarcted canine hearts, differing from its effects on normal hearts.
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