Key result
Lidocaine at 5 mg/liter, but not 1 mg/liter, shifted the steady-state Vmax-Vm relationship to a more negative position by about 5 mV and markedly slowed the reactivation of the early inward current.
Why the study?
Does lidocaine affect the early inward transient sodium current in sheep cardiac Purkinje fibers?
Population
Sheep cardiac Purkinje fibers
Design
Preclinical
Authors
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No clinical implications yet; extends mechanistic understanding of sodium channel effects in animal models.
Does lidocaine affect the early inward transient sodium current in sheep cardiac Purkinje fibers?
Lidocaine at 5 mg/L alters the voltage dependence and slows the reactivation of the early inward sodium current in sheep Purkinje fibers, providing mechanistic insight into its electrophysiological effects.
Weld et al. (1975) studied this question. Lidocaine hydrochloride was evaluated on Steady-state Vmax-Vm relationship and reactivation of early inward transient current. Lidocaine at 5 mg/liter, but not 1 mg/liter, shifted the steady-state Vmax-Vm relationship to a more negative position by about 5 mV and markedly slowed the reactivation of the early inward current.
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